A TRAGIC vehicle collision in Merrijig on Tuesday night June 10 left one dead with three others transported to hospital.

Victoria Police's Major Collision Investigation Unit detectives are investigating the fatal two-vehicle collision which involved the visitors from Melbourne.

It is understood a Kia station wagon and a Mitsubishi Triton ute collided on Mt Buller Road, near Mimosa Drive, about 9.20pm on June 10.

Police confirmed sadly, a 48-year-old Cremorne woman, who was a rear passenger in the ute, died at the scene.

The other rear passenger, a 32-year-old St Kilda man, was airlifted to hospital with serious injuries

The driver, a 22-year-old St Kilda man, was taken to hospital with minor injuries.

The sole occupant of the Kia, a 25-year-old Rowville man, was airlifted to hospital with non-life-threatening injuries.

It is expected he will be interviewed at a later date in relation to the incident.

The exact circumstances surrounding the crash are yet to be determined and investigation remains ongoing.

Anyone who witnessed the incident, has dashcam footage or any other information that could assist police is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at www.crimestoppersvic.com.au